Activation of beta 1 but not beta 3 integrin increases cell traction forces.
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ABSTRACT:
SUBMITTER: Lin GL
PROVIDER: S-EPMC3966909 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Activation of beta 1 but not beta 3 integrin increases cell traction forces.
Lin Grace L GL Cohen Daniel M DM Desai Ravi A RA Breckenridge Mark T MT Gao Lin L Humphries Martin J MJ Chen Christopher S CS
FEBS letters 20130208 6
Cell-generated traction forces induce integrin activation, leading to focal adhesion growth and cell spreading. It remains unknown, however, whether integrin activation feeds back to impact the generation of cytoskeletal tension. Here, we used elastomeric micropost arrays to measure cellular traction forces in wildtype and integrin-null cells. We report that activation of β1 but not β3 integrin, by either increasing density of immobilized fibronectin or treating with manganese, elicited fibrobla ...[more]
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