Ontology highlight
ABSTRACT:
SUBMITTER: Gerhardt DM
PROVIDER: S-EPMC3967047 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Gerhardt Dawson M DM Pajcini Kostandin V KV D'altri Teresa T Tu Lili L Jain Rajan R Xu Lanwei L Chen Michael J MJ Rentschler Stacey S Shestova Olga O Wertheim Gerald B GB Tobias John W JW Kluk Michael M Wood Antony W AW Aster Jon C JC Gimotty Phyllis A PA Epstein Jonathan A JA Speck Nancy N Bigas Anna A Pear Warren S WS
Genes & development 20140301 6
Notch1 is required to generate the earliest embryonic hematopoietic stem cells (HSCs); however since Notch-deficient embryos die early in gestation, additional functions for Notch in embryonic HSC biology have not been described. We used two complementary genetic models to address this important biological question. Unlike Notch1-deficient mice, mice lacking the conserved Notch1 transcriptional activation domain (TAD) show attenuated Notch1 function in vivo and survive until late gestation, succ ...[more]