Ontology highlight
ABSTRACT:
SUBMITTER: Su X
PROVIDER: S-EPMC3967050 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Su Xiaonan X Zhu Guixin G Ding Xiaozhe X Lee Shirley Y SY Dou Yali Y Zhu Bing B Wu Wei W Li Haitao H
Genes & development 20140303 6
Histone modification patterns and their combinatorial readout have emerged as a fundamental mechanism for epigenetic regulation. Here we characterized Spindlin1 as a histone effector that senses a cis-tail histone H3 methylation pattern involving trimethyllysine 4 (H3K4me3) and asymmetric dimethylarginine 8 (H3R8me2a) marks. Spindlin1 consists of triple tudor-like Spin/Ssty repeats. Cocrystal structure determination established concurrent recognition of H3K4me3 and H3R8me2a by Spin/Ssty repeats ...[more]