Ontology highlight
ABSTRACT:
SUBMITTER: Castelli M
PROVIDER: S-EPMC3967097 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
Several organs, including the lungs and kidneys, are formed by epithelial tubes whose proper morphogenesis ensures correct function. This is best exemplified by the kidney, where defective establishment or maintenance of tubular diameter results in polycystic kidney disease, a common genetic disorder. Most polycystic kidney disease cases result from loss-of-function mutations in the PKD1 gene, encoding Polycystin-1, a large receptor of unknown function. Here we demonstrate that PC-1 has an essen ...[more]