Ontology highlight
ABSTRACT:
SUBMITTER: Kleiner RE
PROVIDER: S-EPMC3967239 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Kleiner Ralph E RE Ti Shih-Chieh SC Kapoor Tarun M TM
Journal of the American Chemical Society 20130815 34
Microtubules are hollow tube-like biological polymers required for transport in diverse cellular contexts and are important drug targets. Microtubule function depends on interactions with associated proteins and post-translational modifications at specific sites located on its interior and exterior surfaces. However, we lack strategies to selectively perturb or probe these basic biochemical mechanisms. In this work, by combining amber suppression-mediated non-natural amino acid incorporation and ...[more]