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Effect of zinc supplementation on duration of hospitalization in Tanzanian children presenting with acute pneumonia.


ABSTRACT: Zinc supplementation prevents incident pneumonia in children; however, the effect for pneumonia treatment remains unclear.A randomized, double-blind, placebo-controlled trial of zinc supplements (daily 25 mg) adjunct to antibiotic treatment of radiology-confirmed acute pneumonia was conducted among hospitalized children (6-36 months) in Dar es Salaam, Tanzania.The trial was stopped early due to low enrollment, primarily owing to exclusion of children outside the age range and >3 days of prior illness. Among children enrolled (n = 94), zinc supplementation indicated no beneficial effect on the duration of hospitalization (IRR: 0.69; 95% CI 0.45-1.06; p = 0.09) or the proportion of children who were hospitalized for <3 days (RR: 0.85; 95% CI: 0.57-1.25; p = 0.40) or <5 days (RR: 1.01; 95% CI: 0.83-1.23; p = 0.92) (IRRs and RRs >1.0 favor zinc).Although underpowered, this randomized trial provided no evidence for a beneficial effect of zinc supplementation adjunct to antibiotics for hospitalized children.

SUBMITTER: Fataki MR 

PROVIDER: S-EPMC3967446 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Effect of zinc supplementation on duration of hospitalization in Tanzanian children presenting with acute pneumonia.

Fataki Maulidi R MR   Kisenge Rodrick R RR   Sudfeld Christopher R CR   Aboud Said S   Okuma James J   Mehta Saurabh S   Spiegelman Donna D   Fawzi Wafaie W WW  

Journal of tropical pediatrics 20131105 2


<h4>Background</h4>Zinc supplementation prevents incident pneumonia in children; however, the effect for pneumonia treatment remains unclear.<h4>Methods</h4>A randomized, double-blind, placebo-controlled trial of zinc supplements (daily 25 mg) adjunct to antibiotic treatment of radiology-confirmed acute pneumonia was conducted among hospitalized children (6-36 months) in Dar es Salaam, Tanzania.<h4>Results</h4>The trial was stopped early due to low enrollment, primarily owing to exclusion of chi  ...[more]

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