Ontology highlight
ABSTRACT:
SUBMITTER: Guo Z
PROVIDER: S-EPMC3967760 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Guo Ziyuan Z Zhang Lei L Wu Zheng Z Chen Yuchen Y Wang Fan F Chen Gong G
Cell stem cell 20131219 2
Loss of neurons after brain injury and in neurodegenerative disease is often accompanied by reactive gliosis and scarring, which are difficult to reverse with existing treatment approaches. Here, we show that reactive glial cells in the cortex of stab-injured or Alzheimer's disease (AD) model mice can be directly reprogrammed into functional neurons in vivo using retroviral expression of a single neural transcription factor, NeuroD1. Following expression of NeuroD1, astrocytes were reprogrammed ...[more]