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Herpes zoster caused by vaccine-strain varicella zoster virus in an immunocompetent recipient of zoster vaccine.

ABSTRACT: We report the first laboratory-documented case of herpes zoster caused by the attenuated varicella zoster virus (VZV) contained in Zostavax in a 68-year-old immunocompetent adult with strong evidence of prior wild-type VZV infection. The complete genome sequence of the isolate revealed that the strain carried 15 of 42 (36%) recognized varicella vaccine-associated single-nucleotide polymorphisms, including all 5 of the fixed vaccine markers present in nearly all of the strains in the vaccine. The case of herpes zoster was relatively mild and resolved without complications.

SUBMITTER: Tseng HF

PROVIDER: S-EPMC3967828 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Herpes zoster caused by vaccine-strain varicella zoster virus in an immunocompetent recipient of zoster vaccine.

Tseng Hung Fu HF Schmid D Scott DS Harpaz Rafael R LaRussa Philip P Jensen Nancy J NJ Rivailler Pierre P Radford Kay K Folster Jennifer J Jacobsen Steven J SJ

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20140126 8

We report the first laboratory-documented case of herpes zoster caused by the attenuated varicella zoster virus (VZV) contained in Zostavax in a 68-year-old immunocompetent adult with strong evidence of prior wild-type VZV infection. The complete genome sequence of the isolate revealed that the strain carried 15 of 42 (36%) recognized varicella vaccine-associated single-nucleotide polymorphisms, including all 5 of the fixed vaccine markers present in nearly all of the strains in the vaccine. The ...[more]

PMID: 24470276

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