Ontology highlight
ABSTRACT:
SUBMITTER: Shen JX
PROVIDER: S-EPMC3968274 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Shen Jia X JX Cooper Dermot M F DM
The Biochemical journal 20131001 1
AC2 (adenylate cyclase 2) is stimulated by activation of Gq-coupled muscarinic receptors through PKC (protein kinase C) to generate localized cAMP in HEK (human embryonic kidney)-293 cells. In the present study, we utilized a sensitive live-cell imaging technique to unravel the proteins that play essential roles in a Gq-coupled muscarinic receptor-mediated cAMP signalling complex. We reveal that, upon agonist binding to the Gq-coupled muscarinic receptor, AKAP79 (A-kinase-anchoring protein 79) r ...[more]