A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide.
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ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC3968531 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide.
Kumar Sunil S Miranker Andrew D AD
Chemical communications (Cambridge, England) 20130501 42
A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting β-cells in type II diabetes. ...[more]
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