Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry.
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ABSTRACT:
SUBMITTER: Morris BJ
PROVIDER: S-EPMC3968832 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry.
Morris Brian J BJ Donlon Timothy A TA He Qimei Q Grove John S JS Masaki Kamal H KH Elliott Ayako A Willcox D Craig DC Willcox Bradley J BJ
The journals of gerontology. Series A, Biological sciences and medical sciences 20130614 3
Evidence from model organisms suggests that the insulin/IGF-1 signaling pathway has an important, evolutionarily conserved influence over rate of aging and thus longevity. In humans, the FOXO3 gene is the only widely replicated insulin/IGF-1 signaling pathway gene associated with longevity across multiple populations. Therefore, we conducted a nested case-control study of other insulin/IGF-1 signaling genes and longevity, utilizing a large, homogeneous, long-lived population of American men of J ...[more]
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