Ontology highlight
ABSTRACT:
SUBMITTER: Minett MS
PROVIDER: S-EPMC3969273 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Cell reports 20140116 2
Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction in mice and humans. We examined the role of Nav1.7 as well as Nav1.3, Nav1.8, and Nav1.9 in different mouse models of chronic pain. Constriction-injury-dependent neuropathic pain is abolished when Nav1.7 is deleted in sensory neurons, unlike nerve-transection-related pain, which requires the deletion of Nav1.7 in sensory and sympathetic neurons for pain relief. Sympathetic sprouting that develops in par ...[more]