Acute pretreatment with chloroquine attenuates renal I/R injury in rats.

ABSTRACT:

Background

Acute kidney injury (AKI) still remains an unresolved problem in pharmacotherapy and renal inflammation is a major factor in its development. Chloroquine, a well-known antimalarial drug, posses pleitropic effects as well: antiinflammatory, anticoagulant and vascular actions. The effects of chloroquine on renal function may involve significant increase in urine flow rate, glomerular filtration rate and sodium excretion, as well as stimulation of nitric oxide synthase. However, its role in experimental models of renal I/R injury is unknown. We aimed to analyze the acute effects of a single-dose intravenous chloroquine administered at three different times in the experimental model of I/R injury in rat.

Methods

Rats were subjected to bilateral renal ischemia (45 min)

SUBMITTER: Todorovic Z 

PROVIDER: S-EPMC3969327 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature