Ontology highlight
ABSTRACT:
SUBMITTER: Luo Y
PROVIDER: S-EPMC3969335 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Luo Yunzi Y Huang Hua H Liang Jing J Wang Meng M Lu Lu L Shao Zengyi Z Cobb Ryan E RE Zhao Huimin H
Nature communications 20130101
Polycyclic tetramate macrolactams (PTMs) are a widely distributed class of natural products with important biological activities. However, many of these PTMs have not been characterized. Here we apply a plug-and-play synthetic biology strategy to activate a cryptic PTM biosynthetic gene cluster SGR810-815 from Streptomyces griseus and discover three new PTMs. This gene cluster is highly conserved in phylogenetically diverse bacterial strains and contains an unusual hybrid polyketide synthase-non ...[more]