Controlling escape from angiogenesis inhibitors.
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ABSTRACT:
SUBMITTER: Sennino B
PROVIDER: S-EPMC3969886 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Controlling escape from angiogenesis inhibitors.
Sennino Barbara B McDonald Donald M DM
Nature reviews. Cancer 20121001 10
Selective inhibition of vascular endothelial growth factor (VEGF) increases the efficacy of chemotherapy and has beneficial effects on multiple advanced cancers, but response is often limited and the disease eventually progresses. Changes in the tumour microenvironment--hypoxia among them--that result from vascular pruning, suppressed angiogenesis and other consequences of VEGF inhibition can promote escape and tumour progression. New therapeutic approaches that target pathways that are involved ...[more]
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