Self-consumption: the interplay of autophagy and apoptosis.
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ABSTRACT:
SUBMITTER: Marino G
PROVIDER: S-EPMC3970201 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Self-consumption: the interplay of autophagy and apoptosis.
Mariño Guillermo G Niso-Santano Mireia M Baehrecke Eric H EH Kroemer Guido G
Nature reviews. Molecular cell biology 20140108 2
Autophagy and apoptosis control the turnover of organelles and proteins within cells, and of cells within organisms, respectively, and many stress pathways sequentially elicit autophagy, and apoptosis within the same cell. Generally autophagy blocks the induction of apoptosis, and apoptosis-associated caspase activation shuts off the autophagic process. However, in special cases, autophagy or autophagy-relevant proteins may help to induce apoptosis or necrosis, and autophagy has been shown to de ...[more]
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