Ontology highlight
ABSTRACT:
SUBMITTER: Guo JU
PROVIDER: S-EPMC3970219 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Nature neuroscience 20131222 2
DNA methylation has critical roles in the nervous system and has been traditionally considered to be restricted to CpG dinucleotides in metazoan genomes. Here we show that the single base-resolution DNA methylome from adult mouse dentate neurons consists of both CpG (~75%) and CpH (~25%) methylation (H = A/C/T). Neuronal CpH methylation is conserved in human brains, enriched in regions of low CpG density, depleted at protein-DNA interaction sites and anticorrelated with gene expression. Function ...[more]