Ontology highlight
ABSTRACT:
SUBMITTER: Heiman M
PROVIDER: S-EPMC3970487 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Heiman Myriam M Heilbut Adrian A Francardo Veronica V Kulicke Ruth R Fenster Robert J RJ Kolaczyk Eric D ED Mesirov Jill P JP Surmeier Dalton J DJ Cenci M Angela MA Greengard Paul P
Proceedings of the National Academy of Sciences of the United States of America 20140305 12
Levodopa treatment is the major pharmacotherapy for Parkinson's disease. However, almost all patients receiving levodopa eventually develop debilitating involuntary movements (dyskinesia). Although it is known that striatal spiny projection neurons (SPNs) are involved in the genesis of this movement disorder, the molecular basis of dyskinesia is not understood. In this study, we identify distinct cell-type-specific gene-expression changes that occur in subclasses of SPNs upon induction of a park ...[more]