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Mutant p53 in cancer: new functions and therapeutic opportunities.

ABSTRACT: Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.

SUBMITTER: Muller PA

PROVIDER: S-EPMC3970583 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Mutant p53 in cancer: new functions and therapeutic opportunities.

Muller Patricia A J PA Vousden Karen H KH

Cancer cell 20140301 3

Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types. ...[more]

PMID: 24651012

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