Ontology highlight
ABSTRACT:
SUBMITTER: Maloney A
PROVIDER: S-EPMC3970804 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Maloney Andy A Herskowitz Lawrence J LJ Koch Steven J SJ
PeerJ 20140325
We show for the first time the effects of heavy-hydrogen water ((2)H2O) and heavy-oxygen water (H2 (18)O) on the gliding speed of microtubules on kinesin-1 coated surfaces. Increased fractions of isotopic waters used in the motility solution decreased the gliding speed of microtubules by a maximum of 21% for heavy-hydrogen and 5% for heavy-oxygen water. We also show that gliding microtubule speed returns to its original speed after being treated with heavy-hydrogen water. We discuss possible int ...[more]