Dataset Information

Bayesian latent-class mixed-effect hybrid models for dyadic longitudinal data with non-ignorable dropouts.

ABSTRACT: The analysis of longitudinal dyadic data is challenging due to the complicated correlations within and between dyads, as well as possibly non-ignorable dropouts. Based on a mixed-effects hybrid model, we propose an approach to analyze longitudinal dyadic data with non-ignorable dropouts. We factorize the joint distribution of the measurement and dropout processes into three components: the marginal distribution of random effects, the conditional distribution of the dropout process given the random effects, and the conditional distribution of the measurement process given the random effects and missing data patterns. We model the conditional dropout process using a discrete survival model, and the conditional measurement process using a latent-class pattern-mixture model. These models account for the dyadic interdependence using the "actor" and "partner" effects and dyad-specific random effects. We use the latent-dropout-class approach to address the problem of a large number of missing data patterns caused by the dyadic data structure. We evaluate the performance of the proposed method using a simulation study, and apply our method to a longitudinal dyadic data set that arose from a prostate cancer trial.

SUBMITTER: Ahn J

PROVIDER: S-EPMC3970927 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Bayesian latent-class mixed-effect hybrid models for dyadic longitudinal data with non-ignorable dropouts.

Ahn Jaeil J Liu Suyu S Wang Wenyi W Yuan Ying Y

Biometrics 20131106 4

The analysis of longitudinal dyadic data is challenging due to the complicated correlations within and between dyads, as well as possibly non-ignorable dropouts. Based on a mixed-effects hybrid model, we propose an approach to analyze longitudinal dyadic data with non-ignorable dropouts. We factorize the joint distribution of the measurement and dropout processes into three components: the marginal distribution of random effects, the conditional distribution of the dropout process given the rand ...[more]

PMID: 24328715

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Project description:AimsThe main focus of this study is to illustrate the importance of the statistical analysis in the evaluation of the accuracy of malaria diagnostic tests, without admitting a reference test, exploring a dataset (n=3317) collected in São Tomé and Príncipe.MethodsBayesian Latent Class Models (without and with constraints) are used to estimate the malaria infection prevalence, together with sensitivities, specificities, and predictive values of three diagnostic tests (RDT, Microscopy and PCR), in four subpopulations simultaneously based on a stratified analysis by age groups (< 5, ? 5 years old) and fever status (febrile, afebrile).ResultsIn the afebrile individuals with at least five years old, the posterior mean of the malaria infection prevalence is 3.2% with a highest posterior density interval of [2.3-4.1]. The other three subpopulations (febrile ? 5 years, afebrile or febrile children less than 5 years) present a higher prevalence around 10.3% [8.8-11.7]. In afebrile children under-five years old, the sensitivity of microscopy is 50.5% [37.7-63.2]. In children under-five, the estimated sensitivities/specificities of RDT are 95.4% [90.3-99.5]/93.8% [91.6-96.0]--afebrile--and 94.1% [87.5-99.4]/97.5% [95.5-99.3]--febrile. In individuals with at least five years old are 96.0% [91.5-99.7]/98.7% [98.1-99.2]--afebrile--and 97.9% [95.3-99.8]/97.7% [96.6-98.6]--febrile. The PCR yields the most reliable results in four subpopulations.ConclusionsThe utility of this RDT in the field seems to be relevant. However, in all subpopulations, data provide enough evidence to suggest caution with the positive predictive values of the RDT. Microscopy has poor sensitivity compared to the other tests, particularly, in the afebrile children less than 5 years. This type of findings reveals the danger of statistical analysis based on microscopy as a reference test. Bayesian Latent Class Models provide a powerful tool to evaluate malaria diagnostic tests, taking into account different groups of interest.

Dataset Information

Bayesian latent-class mixed-effect hybrid models for dyadic longitudinal data with non-ignorable dropouts.

Publications

Bayesian latent-class mixed-effect hybrid models for dyadic longitudinal data with non-ignorable dropouts.

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