Dataset Information

Sleep apnea and risk of pneumonia: a nationwide population-based study.

ABSTRACT:

Background

Evidence evaluating the risk of pneumonia in patients with obstructive sleep apnea is limited and mostly focuses on patients who receive continuous positive airway pressure (CPAP) therapy or on pediatric patients. We aimed to explore the risk of incident pneumonia among adults with sleep apnea, either with or without the need of CPAP therapy.

Methods

From Jan. 1, 2000, we identified adult patients with sleep apnea from the Taiwan National Health Insurance Research Database. A control cohort without sleep apnea, matched for age, sex and comorbidities, was selected for comparison. The 2 cohorts were followed until Dec. 31, 2010, and observed for occurrence of pneumonia.

Results

Of the 34,100 patients (6816 study patients and 27,284 matched controls), 2757 (8.09%) had pneumonia during a mean follow-up period of 4.50 years, including 638 (9.36%) study patients and 2119 (7.77%) controls. Kaplan-Meier analysis showed a higher incidence of pneumonia among patients with sleep apnea (log rank test, p < 0.001). After multivariate adjustment, patients with sleep apnea experienced a 1.20-fold (95% confidence interval 1.10-1.31) increase in incident pneumonia. The risk was even higher among patients who received CPAP therapy.

Interpretation

Sleep apnea appeared to confer a higher risk for future pneumonia, possibly in a severity-dependent manner.

SUBMITTER: Su VY

PROVIDER: S-EPMC3971026 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Sleep apnea and risk of pneumonia: a nationwide population-based study.

Su Vincent Yi-Fong VY Liu Chia-Jen CJ Wang Hsin-Kai HK Wu Li-An LA Chang Shi-Chuan SC Perng Diahn-Warng DW Su Wei-Juin WJ Chen Yuh-Min YM Lin Elizabeth Ya-Hsuan EY Chen Tzeng-Ji TJ Chou Kun-Ta KT

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20140303 6

<h4>Background</h4>Evidence evaluating the risk of pneumonia in patients with obstructive sleep apnea is limited and mostly focuses on patients who receive continuous positive airway pressure (CPAP) therapy or on pediatric patients. We aimed to explore the risk of incident pneumonia among adults with sleep apnea, either with or without the need of CPAP therapy.<h4>Methods</h4>From Jan. 1, 2000, we identified adult patients with sleep apnea from the Taiwan National Health Insurance Research Datab ...[more]

PMID: 24591276

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Dataset Information

Sleep apnea and risk of pneumonia: a nationwide population-based study.

Background

Methods

Results

Interpretation

Publications

Sleep apnea and risk of pneumonia: a nationwide population-based study.

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