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Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome.


ABSTRACT: Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.

SUBMITTER: Baxter L 

PROVIDER: S-EPMC3971456 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome.

Baxter Laura L   Tripathy Sucheta S   Ishaque Naveed N   Boot Nico N   Cabral Adriana A   Kemen Eric E   Thines Marco M   Ah-Fong Audrey A   Anderson Ryan R   Badejoko Wole W   Bittner-Eddy Peter P   Boore Jeffrey L JL   Chibucos Marcus C MC   Coates Mary M   Dehal Paramvir P   Delehaunty Kim K   Dong Suomeng S   Downton Polly P   Dumas Bernard B   Fabro Georgina G   Fronick Catrina C   Fuerstenberg Susan I SI   Fulton Lucinda L   Gaulin Elodie E   Govers Francine F   Hughes Linda L   Humphray Sean S   Jiang Rays H Y RHY   Judelson Howard H   Kamoun Sophien S   Kyung Kim K   Meijer Harold H   Minx Patrick P   Morris Paul P   Nelson Joanne J   Phuntumart Vipa V   Qutob Dinah D   Rehmany Anne A   Rougon-Cardoso Alejandra A   Ryden Peter P   Torto-Alalibo Trudy T   Studholme David D   Wang Yuanchao Y   Win Joe J   Wood Jo J   Clifton Sandra W SW   Rogers Jane J   Van den Ackerveken Guido G   Jones Jonathan D G JDG   McDowell John M JM   Beynon Jim J   Tyler Brett M BM  

Science (New York, N.Y.) 20101201 6010


Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrop  ...[more]

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