Increased substitution rates surrounding low-complexity regions within primate proteins.
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ABSTRACT:
SUBMITTER: Lenz C
PROVIDER: S-EPMC3971593 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Increased substitution rates surrounding low-complexity regions within primate proteins.
Lenz Carolyn C Haerty Wilfried W Golding G Brian GB
Genome biology and evolution 20140301 3
Previous studies have found that DNA-flanking low-complexity regions (LCRs) have an increased substitution rate. Here, the substitution rate was confirmed to increase in the vicinity of LCRs in several primate species, including humans. This effect was also found among human sequences from the 1000 Genomes Project. A strong correlation was found between average substitution rate per site and distance from the LCR, as well as the proportion of genes with gaps in the alignment at each site and dis ...[more]
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