Ontology highlight
ABSTRACT:
SUBMITTER: Dhara M
PROVIDER: S-EPMC3971750 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Dhara Madhurima M Yarzagaray Antonio A Schwarz Yvonne Y Dutta Soumyajit S Grabner Chad C Moghadam Paanteha K PK Bost Anneka A Schirra Claudia C Rettig Jens J Reim Kerstin K Brose Nils N Mohrmann Ralf R Bruns Dieter D
The Journal of cell biology 20140301 7
ComplexinII (CpxII) and SynaptotagminI (SytI) have been implicated in regulating the function of SNARE proteins in exocytosis, but their precise mode of action and potential interplay have remained unknown. In this paper, we show that CpxII increases Ca(2+)-triggered vesicle exocytosis and accelerates its secretory rates, providing two independent, but synergistic, functions to enhance synchronous secretion. Specifically, we demonstrate that the C-terminal domain of CpxII increases the pool of p ...[more]