Ontology highlight
ABSTRACT:
SUBMITTER: Gimenez-Cassina A
PROVIDER: S-EPMC3971904 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Giménez-Cassina Alfredo A Garcia-Haro Luisa L Choi Cheol Soo CS Osundiji Mayowa A MA Lane Elizabeth A EA Huang Hu H Yildirim Muhammed A MA Szlyk Benjamin B Fisher Jill K JK Polak Klaudia K Patton Elaura E Wiwczar Jessica J Godes Marina M Lee Dae Ho DH Robertson Kirsten K Kim Sheene S Kulkarni Ameya A Distefano Alberto A Samuel Varman V Cline Gary G Kim Young-Bum YB Shulman Gerald I GI Danial Nika N NN
Cell metabolism 20140201 2
The homeostatic balance of hepatic glucose utilization, storage, and production is exquisitely controlled by hormonal signals and hepatic carbon metabolism during fed and fasted states. How the liver senses extracellular glucose to cue glucose utilization versus production is not fully understood. We show that the physiologic balance of hepatic glycolysis and gluconeogenesis is regulated by Bcl-2-associated agonist of cell death (BAD), a protein with roles in apoptosis and metabolism. BAD defici ...[more]