The genetics of pro-arrhythmic adverse drug reactions.
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ABSTRACT:
SUBMITTER: Petropoulou E
PROVIDER: S-EPMC3971979 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
The genetics of pro-arrhythmic adverse drug reactions.
Petropoulou Evmorfia E Jamshidi Yalda Y Behr Elijah R ER
British journal of clinical pharmacology 20140401 4
Ventricular arrhythmia induced by drugs (pro-arrythmia) is an uncommon event, whose occurrence is unpredictable but potentially fatal. The ability of a variety of medications to induce these arrhythmias is a significant problem facing the pharmaceutical industry. Genetic variants have been shown to play a role in adverse events and are also known to influence an individual's optimal drug dose. This review provides an overview of the current understanding of the role of genetic variants in modula ...[more]
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