Ontology highlight
ABSTRACT:
SUBMITTER: Zhang YT
PROVIDER: S-EPMC3972149 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Zhang Yan-Ting YT Xu Li-Hui LH Lu Qun Q Liu Kun-Peng KP Liu Pei-Yan PY Ji Fang F Liu Xiao-Ming XM Ouyang Dong-Yun DY He Xian-Hui XH
PloS one 20140401 4
Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis. However, the underlying molecular mechanism of such anticancer effects remains incompletely understood. In this study, we showed that CuB treatment rapidly induced vasodilator-stimulated phosphoprotein (VASP) phosphorylation (i.e. activation) at the Ser157 residue and generated VASP clumps which were co-localized with ...[more]