Pol? deficiency increases resistance to oxidative damage and delays liver aging.
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ABSTRACT:
SUBMITTER: Escudero B
PROVIDER: S-EPMC3972199 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Polμ deficiency increases resistance to oxidative damage and delays liver aging.
Escudero Beatriz B Lucas Daniel D Albo Carmen C Dhup Suveera S Bacher Jeff W JW Sánchez-Muñoz Aránzazu A Fernández Margarita M Rivera-Torres José J Carmona Rosa M RM Fuster Encarnación E Carreiro Candelas C Bernad Raquel R González Manuel A MA Andrés Vicente V Blanco Luis L Roche Enrique E Fabregat Isabel I Samper Enrique E Bernad Antonio A
PloS one 20140401 4
Polμ is an error-prone PolX polymerase that contributes to classical NHEJ DNA repair. Mice lacking Polμ (Polμ(-/-)) show altered hematopoiesis homeostasis and DSB repair and a more pronounced nucleolytic resection of some V(D)J junctions. We previously showed that Polμ(-/-) mice have increased learning capacity at old ages, suggesting delayed brain aging. Here we investigated the effect of Polμ(-/-) deficiency on liver aging. We found that old Polμ(-/-) mice (>20 month) have greater liver regene ...[more]
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