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P16 status, pathologic and clinical characteristics, biomolecular signature, and long-term outcomes in head and neck squamous cell carcinomas of unknown primary.

ABSTRACT: BACKGROUND:The purpose of this study was to report associations between p16 status, clinicopathologic characteristics, and outcomes for head and neck squamous cell carcinoma of unknown primary (CUP). METHODS:Specimens of squamous cell CUP were reanalyzed. Human papillomavirus (HPV) status was determined by p16 stain. A tissue microarray (TMA) was constructed to evaluate biomarkers potentially prognostic in head and neck squamous cell carcinoma (HNSCC). RESULTS:A majority of the population (n?=?26; 74%) was p16 positive (+). Prognostic factors benefiting survival were p16+ status (p?

SUBMITTER: Keller LM

PROVIDER: S-EPMC3972378 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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p16 status, pathologic and clinical characteristics, biomolecular signature, and long-term outcomes in head and neck squamous cell carcinomas of unknown primary.

Keller Lanea M LM Galloway Thomas J TJ Holdbrook Thomas T Ruth Karen K Yang Donghua D Dubyk Cara C Flieder Douglas D Lango Miriam N MN Mehra Ranee R Burtness Barbara B Ridge John A JA

Head & neck 20140113 12

<h4>Background</h4>The purpose of this study was to report associations between p16 status, clinicopathologic characteristics, and outcomes for head and neck squamous cell carcinoma of unknown primary (CUP).<h4>Methods</h4>Specimens of squamous cell CUP were reanalyzed. Human papillomavirus (HPV) status was determined by p16 stain. A tissue microarray (TMA) was constructed to evaluate biomarkers potentially prognostic in head and neck squamous cell carcinoma (HNSCC).<h4>Results</h4>A majority of ...[more]

PMID: 24115269

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