Ontology highlight
ABSTRACT:
SUBMITTER: Russnes HG
PROVIDER: S-EPMC3972440 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Russnes Hege G HG Vollan Hans Kristian Moen HKM Lingjærde Ole Christian OC Krasnitz Alexander A Lundin Pär P Naume Bjørn B Sørlie Therese T Borgen Elin E Rye Inga H IH Langerød Anita A Chin Suet-Feung SF Teschendorff Andrew E AE Stephens Philip J PJ Månér Susanne S Schlichting Ellen E Baumbusch Lars O LO Kåresen Rolf R Stratton Michael P MP Wigler Michael M Caldas Carlos C Zetterberg Anders A Hicks James J Børresen-Dale Anne-Lise AL
Science translational medicine 20100601 38
Distinct molecular subtypes of breast carcinomas have been identified, but translation into clinical use has been limited. We have developed two platform-independent algorithms to explore genomic architectural distortion using array comparative genomic hybridization data to measure (i) whole-arm gains and losses [whole-arm aberration index (WAAI)] and (ii) complex rearrangements [complex arm aberration index (CAAI)]. By applying CAAI and WAAI to data from 595 breast cancer patients, we were able ...[more]