Rapamycin: one drug, many effects.
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ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC3972801 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Rapamycin: one drug, many effects.
Li Jing J Kim Sang Gyun SG Blenis John J
Cell metabolism 20140206 3
The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell growth and metabolism. Deregulation of the mTOR pathway has been implicated in a number of human diseases such as cancer, diabetes, obesity, neurological diseases, and genetic disorders. Rapamycin, a specific inhibitor of mTOR, has been shown to be useful in the treatment of certain diseases. Here we discuss its mechanism of action and highlight recent findings regarding the effects and limitations of rapamy ...[more]
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