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Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells.

ABSTRACT: A therapeutic aptamer-lipid-poly(lactide-co-glycolic acid) hybrid nanoparticle-based drug delivery system was prepared and characterized. This system can co-deliver two different drugs with distinct solubility and different anticancer mechanisms to target cancer cells with high specificity and efficiency.

SUBMITTER: Huang F 

PROVIDER: S-EPMC3973031 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells.

Huang Fujian F   You Mingxu M   Chen Tao T   Zhu Guizhi G   Liang Haojun H   Tan Weihong W  

Chemical communications (Cambridge, England) 20140301 23

A therapeutic aptamer-lipid-poly(lactide-co-glycolic acid) hybrid nanoparticle-based drug delivery system was prepared and characterized. This system can co-deliver two different drugs with distinct solubility and different anticancer mechanisms to target cancer cells with high specificity and efficiency. ...[more]

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