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Recent developments in the treatment of age-related macular degeneration.

ABSTRACT: Age-related macular degeneration (AMD) is a common cause of visual loss in the elderly, with increasing prevalence due to increasing life expectancy. While the introduction of anti-VEGF therapy has improved outcomes, there are still major unmet needs and gaps in the understanding of underlying biological processes. These include early, intermediate, and atrophic disease stages. Recent studies have assessed therapeutic approaches addressing various disease-associated pathways, including complement inhibitors. Drug-delivery aspects are also relevant, as many agents have to be administered repeatedly. Herein, relevant pathogenetic factors and underlying mechanisms as well as recent and potential therapeutic approaches are reviewed.

SUBMITTER: Holz FG

PROVIDER: S-EPMC3973093 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Recent developments in the treatment of age-related macular degeneration.

Holz Frank G FG Schmitz-Valckenberg Steffen S Fleckenstein Monika M

The Journal of clinical investigation 20140401 4

Age-related macular degeneration (AMD) is a common cause of visual loss in the elderly, with increasing prevalence due to increasing life expectancy. While the introduction of anti-VEGF therapy has improved outcomes, there are still major unmet needs and gaps in the understanding of underlying biological processes. These include early, intermediate, and atrophic disease stages. Recent studies have assessed therapeutic approaches addressing various disease-associated pathways, including complemen ...[more]

PMID: 24691477

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Recent developments in age-related macular degeneration: a review.

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Age-related macular degeneration.

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Age related macular degeneration.

Project description: Not available

| S-EPMC1125371 | biostudies-literature

Project description:Age-related macular degeneration is the leading cause of visual impairment among older adults in the developed world. Epidemiological studies have revealed a number of genetic, ocular and environmental risk factors for this condition, which can be addressed by disease reduction strategies. We discuss the various treatment options for dry and exudative age-related macular degeneration available and explain how the recommended treatment depends on the exact type, location and extent of the degeneration. Currently, vascular endothelial growth factor (VEGF) inhibition therapy is the best available treatment for exudative age-related macular degeneration but is limited by the need for repeated intravitreal injections. The current treatment regime is being refined through research on optimal treatment frequency and duration and type of anti-VEGF drug. Different modes of drug delivery are being developed and in the future other methods of VEGF inhibition may be used.

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Treatment of age-related macular degeneration: focus on ranibizumab.

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