Ontology highlight
ABSTRACT:
SUBMITTER: Munoz JL
PROVIDER: S-EPMC3973225 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Munoz J L JL Rodriguez-Cruz V V Greco S J SJ Ramkissoon S H SH Ligon K L KL Rameshwar P P
Cell death & disease 20140327
Glioblastoma Multiforme (GBM) is an aggressive adult primary brain tumor with poor prognosis. GBM patients develop resistance to the frontline chemotherapy, temozolomide (TMZ). As the connexins (Cx) have been shown to have a complex role in GBM, we investigated the role of Cx43 in TMZ resistance. Cx43 was increased in the TMZ-resistant low passage and cell lines. This correlated with the data in The Cancer Genome Atlas. Cx43 knockdown, reporter gene assays, chromatin immunoprecipitation assay, r ...[more]