Ontology highlight
ABSTRACT:
SUBMITTER: Yamaguchi H
PROVIDER: S-EPMC3973346 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Nucleic acids research 20131226 6
We have determined the three-dimensional (3D) structure of DNA duplex that includes tandem Hg(II)-mediated T-T base pairs (thymine-Hg(II)-thymine, T-Hg(II)-T) with NMR spectroscopy in solution. This is the first 3D structure of metallo-DNA (covalently metallated DNA) composed exclusively of 'NATURAL' bases. The T-Hg(II)-T base pairs whose chemical structure was determined with the (15)N NMR spectroscopy were well accommodated in a B-form double helix, mimicking normal Watson-Crick base pairs. Th ...[more]