Dupuytren's disease and the risk of malignant neoplasms.
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ABSTRACT:
SUBMITTER: Zyluk A
PROVIDER: S-EPMC3973858 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
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Dupuytren's disease and the risk of malignant neoplasms.
Zyluk Andrzej A Paszkowska-Szczur Katarzyna K Gupta Satish S Scott Rodney J RJ Lubiński Jan J Dębniak Tadeusz T
Hereditary cancer in clinical practice 20140306 1
The object of this study was the investigation of the risk of occurrence of malignant neoplasms in 508 patients with Dupuytren's disease (DD) and in 2157 of their 1st degree relatives. In the first stage of the study, we evaluated the tumour spectrum as well as the age of the patient at diagnosis of cancers in DD families along with the observed and expected frequencies of malignancies. In the second stage of the study, we examined the distribution of 20 common mutations/polymorphisms in 12 know ...[more]
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