Dataset Information
Catalytic asymmetric reactions for organic synthesis: the combined C-H activation/Cope rearrangement.
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ABSTRACT:
SUBMITTER: Davies HM
PROVIDER: S-EPMC397407 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Publications
Catalytic asymmetric reactions for organic synthesis: the combined C-H activation/Cope rearrangement.
Proceedings of the National Academy of Sciences of the United States of America 20040315 15
The development of new catalytic asymmetric reactions can lead to exciting new strategies for organic synthesis. This article describes the synthetic utility of the combined C-H activation/Cope rearrangement, achieved by dirhodium tetraprolinate-catalyzed reaction of vinyldiazoacetates with compounds containing allylic C-H bonds. The transformation is highly diastereoselective and enantioselective. The product distribution, however, is highly substrate dependent, the major side products being ei ...[more]