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PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion.


ABSTRACT: Male BALB/c mice fed with either a regular or high fat diet were exposed to 0, 5 or 20 mg/kg perfluorooctane sulfonate (PFOS) for 14 days. Increased body weight, serum glucose, cholesterol and lipoprotein levels were observed in mice given a high fat diet. However, all PFOS-treated mice got reduced levels of serum lipid and lipoprotein. Decreasing liver glycogen content was also observed, accompanied by reduced serum glucose levels. Histological and ultrastructural examination detected more lipid droplets accumulated in hepatocytes after PFOS exposure. Moreover, transcripitonal activity of lipid metabolism related genes suggests that PFOS toxicity is probably unrelevant to PPAR?'s transcription. The present study demonstrates a lipid disturbance caused by PFOS and thus point to its role in inhibiting the secretion and normal function of low density lipoproteins.

SUBMITTER: Wang L 

PROVIDER: S-EPMC3974142 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion.

Wang Ling L   Wang Yu Y   Liang Yong Y   Li Jia J   Liu Yuchen Y   Zhang Jie J   Zhang Aiqian A   Fu Jianjie J   Jiang Guibin G  

Scientific reports 20140403


Male BALB/c mice fed with either a regular or high fat diet were exposed to 0, 5 or 20 mg/kg perfluorooctane sulfonate (PFOS) for 14 days. Increased body weight, serum glucose, cholesterol and lipoprotein levels were observed in mice given a high fat diet. However, all PFOS-treated mice got reduced levels of serum lipid and lipoprotein. Decreasing liver glycogen content was also observed, accompanied by reduced serum glucose levels. Histological and ultrastructural examination detected more lipi  ...[more]

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