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Management of plastic bronchitis with nebulized tissue plasminogen activator: another brick in the wall.


ABSTRACT: Plastic bronchitis is a rare complication of a variety of respiratory diseases and congenital heart disease surgery, particularly Fontan procedure. Bronchial casts with rubber-like consistency develop acutely and may cause severe life-threatening respiratory distress. The management of plastic bronchitis is yet not well defined. Early intermittent, self-administered nebulization of tissue plasminogen activator was found to be effective in preventing deterioration of acute respiratory symptoms in a patient with primary ciliary dyskinesia and recurrent cast formation. Further investigation into new therapeutic strategies for this devastating disease is advocated.

SUBMITTER: Colaneri M 

PROVIDER: S-EPMC3974171 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Management of plastic bronchitis with nebulized tissue plasminogen activator: another brick in the wall.

Colaneri Massimo M   Quarti Andrea A   Pozzi Marco M   Gasparini Stefano S   Carloni Ines I   de Benedictis Fernando Maria FM  

Italian journal of pediatrics 20140213 1


Plastic bronchitis is a rare complication of a variety of respiratory diseases and congenital heart disease surgery, particularly Fontan procedure. Bronchial casts with rubber-like consistency develop acutely and may cause severe life-threatening respiratory distress. The management of plastic bronchitis is yet not well defined. Early intermittent, self-administered nebulization of tissue plasminogen activator was found to be effective in preventing deterioration of acute respiratory symptoms in  ...[more]

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