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Differences in structural elements of Bcr-Abl oncoprotein isoforms in Chronic Myelogenous Leukemia.


ABSTRACT: in silico modeling, using Psipred and ExPASy servers was employed to determine the structural elements of Bcr-Abl oncoprotein (p210(BCR-ABL)) isoforms, b2a2 and b3a2, expressed in Chronic Myelogenous Leukemia (CML). Both these proteins are tyrosine kinases having masses of 210-kDa and differing only by 25 amino acids coded by the b3 exonand an amino acidsubstitution (Glu903Asp). The secondary structure elements of the two proteins show differences in five ?-helices and nine ?-strands which relates to differences in the SH3, SH2, SH1 and DNA-binding domains. These differences can result in different roles played by the two isoforms in mediating signal transduction during the course of CML.

SUBMITTER: Hai A 

PROVIDER: S-EPMC3974235 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Differences in structural elements of Bcr-Abl oncoprotein isoforms in Chronic Myelogenous Leukemia.

Hai Abdul A   Kizilbash Nadeem A NA   Zaidi Syeda Huma H SH   Alruwaili Jamal J   Shahzad Khuram K  

Bioinformation 20140319 3


in silico modeling, using Psipred and ExPASy servers was employed to determine the structural elements of Bcr-Abl oncoprotein (p210(BCR-ABL)) isoforms, b2a2 and b3a2, expressed in Chronic Myelogenous Leukemia (CML). Both these proteins are tyrosine kinases having masses of 210-kDa and differing only by 25 amino acids coded by the b3 exonand an amino acidsubstitution (Glu903Asp). The secondary structure elements of the two proteins show differences in five α-helices and nine β-strands which relat  ...[more]

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