Ontology highlight
ABSTRACT:
SUBMITTER: Hai A
PROVIDER: S-EPMC3974235 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Hai Abdul A Kizilbash Nadeem A NA Zaidi Syeda Huma H SH Alruwaili Jamal J Shahzad Khuram K
Bioinformation 20140319 3
in silico modeling, using Psipred and ExPASy servers was employed to determine the structural elements of Bcr-Abl oncoprotein (p210(BCR-ABL)) isoforms, b2a2 and b3a2, expressed in Chronic Myelogenous Leukemia (CML). Both these proteins are tyrosine kinases having masses of 210-kDa and differing only by 25 amino acids coded by the b3 exonand an amino acidsubstitution (Glu903Asp). The secondary structure elements of the two proteins show differences in five α-helices and nine β-strands which relat ...[more]