Ontology highlight
ABSTRACT:
SUBMITTER: Noren NK
PROVIDER: S-EPMC397426 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Noren Nicole K NK Lu Mark M Freeman Andrew L AL Koolpe Mitchell M Pasquale Elena B EB
Proceedings of the National Academy of Sciences of the United States of America 20040405 15
Receptor tyrosine kinases of the Eph family are up-regulated in different types of cancer. EphB4 and its ligand ephrin-B2 have been linked to breast cancer, but little is known about how this receptor-ligand complex may contribute to oncogenesis. The Eph receptors transmit forward signals via their kinase domain and reverse signals via their transmembrane ephrin-B ligands. Therefore, we used EphB4 that were lacking the kinase domain and tagged with EGFP (EphB4 Delta C-EGFP) to differentiate betw ...[more]