Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging.

ABSTRACT:

Objective

Late-life depression (LLD) has a substantial public health impact and is both a risk factor for and a prodrome of dementia. Positron emission tomography (PET) studies of cerebral glucose metabolism have demonstrated sensitivity in evaluating neural circuitry involved in depression, aging, incipient cognitive decline, and dementia. The present study evaluated the long term effects of a course of antidepressant treatment on glucose metabolism in LLD patients.

Methods

Nine LLD patients and seven non-depressed control subjects underwent clinical and cognitive evaluations as well as brain magnetic resonance imaging and PET studies of cerebral glucose metabolism at baseline, after 8 weeks of treatment with citalopram for a major depressive episode (patients only), and at

SUBMITTER: Marano CM 

PROVIDER: S-EPMC3974580 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature