Ontology highlight
ABSTRACT:
SUBMITTER: Pan R
PROVIDER: S-EPMC3975047 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Pan Rongqing R Hogdal Leah J LJ Benito Juliana M JM Bucci Donna D Han Lina L Borthakur Gautam G Cortes Jorge J DeAngelo Daniel J DJ Debose Lakeisha L Mu Hong H Döhner Hartmut H Gaidzik Verena I VI Galinsky Ilene I Golfman Leonard S LS Haferlach Torsten T Harutyunyan Karine G KG Hu Jianhua J Leverson Joel D JD Marcucci Guido G Müschen Markus M Newman Rachel R Park Eugene E Ruvolo Peter P PP Ruvolo Vivian V Ryan Jeremy J Schindela Sonja S Zweidler-McKay Patrick P Stone Richard M RM Kantarjian Hagop H Andreeff Michael M Konopleva Marina M Letai Anthony G AG
Cancer discovery 20131217 3
B-cell leukemia/lymphoma 2 (BCL-2) prevents commitment to programmed cell death at the mitochondrion. It remains a challenge to identify those tumors that are best treated by inhibition of BCL-2. Here, we demonstrate that acute myeloid leukemia (AML) cell lines, primary patient samples, and murine primary xenografts are very sensitive to treatment with the selective BCL-2 antagonist ABT-199. In primary patient cells, the median IC50 was approximately 10 nmol/L, and cell death occurred within 2 h ...[more]