Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction.
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ABSTRACT:
SUBMITTER: Sen A
PROVIDER: S-EPMC3975049 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
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Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction.
Sen Anagha A Most Patrick P Peppel Karsten K
FEBS letters 20140131 6
Exposure to pro-inflammatory cytokines, such as Angiotensin II, endothelin-1 or TNF leads to endothelial dysfunction, characterized by the reduced production of nitric oxide via endothelial nitric oxide synthase (eNOS). We recently identified the Ca(2+) binding protein S100A1 as an essential factor required for eNOS activity. Here we report that pro-inflammatory cytokines down-regulate expression of S100A1 in primary human microvascular endothelial cells (HMVECs) via induction of microRNA-138 (m ...[more]
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