Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC3975057 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Chen Yibin Y Chen Qiang Q McEachin Richard C RC Cavalcoli James D JD Yu Xiaochun X
Genome research 20140108 4
H2A.B is a unique histone H2A variant that only exists in mammals. Here we found that H2A.B is ubiquitously expressed in major organs. Genome-wide analysis of H2A.B in mouse ES cells shows that H2A.B is associated with methylated DNA in gene body regions. Moreover, H2A.B-enriched gene loci are actively transcribed. One typical example is that H2A.B is enriched in a set of differentially methylated regions at imprinted loci and facilitates transcription elongation. These results suggest that H2A. ...[more]