Ontology highlight
ABSTRACT:
SUBMITTER: Fish RJ
PROVIDER: S-EPMC3975262 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Fish Richard J RJ Di Sanza Corinne C Neerman-Arbez Marguerite M
Blood 20140219 14
Mutations in the human fibrinogen genes can lead to the absence of circulating fibrinogen and cause congenital afibrinogenemia. This rare bleeding disorder is associated with a variable phenotype, which may be influenced by environment and genotype. Here, we present a zebrafish model of afibrinogenemia. We introduced targeted mutations into the zebrafish fga gene using zinc finger nuclease technology. Animals carrying 3 distinct frameshift mutations in fga were raised and bred to produce homozyg ...[more]