Ontology highlight
ABSTRACT:
SUBMITTER: Bajda M
PROVIDER: S-EPMC3975444 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20140324 3
β-Secretase (BACE-1) constitutes an important target for search of anti-Alzheimer's drugs. The first inhibitors of this enzyme were peptidic compounds with high molecular weight and low bioavailability. Therefore, the search for new efficient non-peptidic inhibitors has been undertaken by many scientific groups. We started our work from the development of in silico methodology for the design of novel BACE-1 ligands. It was validated on the basis of crystal structures of complexes with inhibitors ...[more]