Unknown

Dataset Information

0

Cysteine- rich secretory protein 3 (CRISP3), ERG and PTEN define a molecular subtype of prostate cancer with implication to patients' prognosis.

ABSTRACT: Cysteine- rich secretory protein 3 (CRISP3) prognostic significance in prostate cancer (PCA) has generated mixed result. Herein, we investigated and independently validated CRISP3 expression in relation to ERG and PTEN genomic aberrations and clinical outcome. CRISP3 protein expression was examined by immunohistochemistry using a cohort of patients with localized PCA (n?=?215) and castration resistant PCA (CRPC) (n?=?46). The Memorial Sloan Kettering (MSKCC) and Swedish cohorts were used for prognostic validation. Results showed, CRISP3 protein intensity to be significantly associated with neoplastic epithelium, being highest in CRPC vs. benign prostate tissue (p?

SUBMITTER: Al Bashir S 

PROVIDER: S-EPMC3975646 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Cysteine- rich secretory protein 3 (CRISP3), ERG and PTEN define a molecular subtype of prostate cancer with implication to patients' prognosis.

Al Bashir Samir S   Alshalalfa Mohammed M   Hegazy Samar A SA   Dolph Michael M   Donnelly Bryan B   Bismar Tarek A TA  

Journal of hematology & oncology 20140307

Cysteine- rich secretory protein 3 (CRISP3) prognostic significance in prostate cancer (PCA) has generated mixed result. Herein, we investigated and independently validated CRISP3 expression in relation to ERG and PTEN genomic aberrations and clinical outcome. CRISP3 protein expression was examined by immunohistochemistry using a cohort of patients with localized PCA (n = 215) and castration resistant PCA (CRPC) (n = 46). The Memorial Sloan Kettering (MSKCC) and Swedish cohorts were used for pro  ...[more]

Similar Datasets

Unknown Cysteine-rich secretory protein-3 (CRISP3) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene.
| S-EPMC3141037 | biostudies-literature
Unknown Cancer Prognosis Defined by the Combined Analysis of 8q, PTEN and ERG.
| S-EPMC5143339 | biostudies-literature
Unknown The role of cysteine-rich secretory proteins in male fertility.
| S-EPMC3739402 | biostudies-other
Unknown Evolutionary analysis of genes coding for Cysteine-RIch Secretory Proteins (CRISPs) in mammals.
| S-EPMC7278046 | biostudies-literature
Unknown Impaired sperm fertilizing ability in mice lacking Cysteine-RIch Secretory Protein 1 (CRISP1).
| S-EPMC2603034 | biostudies-literature
Transcriptomics A cysteine-rich secretory protein involves in phytohormone melatonin mediated plant resistance to CGMMV
2022-12-30 | GSE221904 | GEO
Unknown Cysteine-Rich Atrial Secretory Protein from the Snail Achatina achatina: Purification and Structural Characterization.
| S-EPMC4596865 | biostudies-literature
Unknown MicroRNA-27a-mediated repression of cysteine-rich secretory protein 2 translation in asthenoteratozoospermic patients.
| S-EPMC5566855 | biostudies-literature
Unknown Structures of pseudechetoxin and pseudecin, two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels: implications for movement of the C-terminal cysteine-rich domain.
| S-EPMC2725782 | biostudies-literature
Unknown Docetaxel Treatment in PTEN- and ERG-aberrant Metastatic Prostate Cancers.
| S-EPMC5995869 | biostudies-other