Ontology highlight
ABSTRACT:
SUBMITTER: Caplin B
PROVIDER: S-EPMC3975829 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Arteriosclerosis, thrombosis, and vascular biology 20120329 6
The asymmetric methylarginines inhibit nitric oxide synthesis in vivo by competing with L-arginine at the active site of nitric oxide synthase. High circulating levels of asymmetric dimethylarginine predict adverse outcomes, specifically vascular events but there is now increasing experimental and epidemiological evidence that these molecules, and the enzymes that regulate this pathway, play a mechanistic role in cardiovascular diseases. Recent data have provided insight into the impact of alter ...[more]